MBX-8025 obtained another ODD for treatment of patients with Frederickson Type I or V hyperlipoproteinemia

Industry News

MBX-8025 obtained another ODD from the FDA for the treatment of patients with Frederickson Type I or V hyperlipoproteinemia.  MBX-8025 is a potent and selective peroxisome proliferator-activated receptor delta (PPARδ) agonist under development by CymaBay Therapeutics, a biopharmaceutical company based in Newark, NJ.  It received ODD from the FDA last month for homozygous familial hypercholesterolemia (HoFH).  Hyperlipoproteinemia is a group of disorders with abnormally high levels of any or all lipids and/or lipoproteins in the blood.  Familial hyperlipoproteinemia is usually hereditary and Frederickson Type I or V hyperlipoproteinemia is relatively rare among hyperlipoproteinemia.  Left untreated, this group of patients would develop premature cardiovascular disease that can result in myocardial infarction, ischemic stroke and premature death.  Being a potent agonist for PPARδ, a nuclear receptor important for lipid transport, storage and metabolism in liver and muscle, MBX-8025 has shown favorable effects on lipid and metabolic parameters in clinical trials in patients with dyslipidemia.


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