MBX-8025 obtained another ODD for treatment of patients with Frederickson Type I or V hyperlipoproteinemia

Industry News

MBX-8025 obtained another ODD from the FDA for the treatment of patients with Frederickson Type I or V hyperlipoproteinemia.  MBX-8025 is a potent and selective peroxisome proliferator-activated receptor delta (PPARδ) agonist under development by CymaBay Therapeutics, a biopharmaceutical company based in Newark, NJ.  It received ODD from the FDA last month for homozygous familial hypercholesterolemia (HoFH).  Hyperlipoproteinemia is a group of disorders with abnormally high levels of any or all lipids and/or lipoproteins in the blood.  Familial hyperlipoproteinemia is usually hereditary and Frederickson Type I or V hyperlipoproteinemia is relatively rare among hyperlipoproteinemia.  Left untreated, this group of patients would develop premature cardiovascular disease that can result in myocardial infarction, ischemic stroke and premature death.  Being a potent agonist for PPARδ, a nuclear receptor important for lipid transport, storage and metabolism in liver and muscle, MBX-8025 has shown favorable effects on lipid and metabolic parameters in clinical trials in patients with dyslipidemia.

 

Related Links:

http://ir.stockpr.com/cymabay/press-releases/detail/324
http://www.cymabay.com/pipeline_mbx8025.html
http://omim.org/entry/144650
http://www.omim.org/entry/238600?search=HYPERLIPOPROTEINEMIA&highlight=hyperlipoproteinemia
http://www.gpnotebook.co.uk/simplepage.cfm?ID=x20030319112941821100&linkID=66772&cook=yes

Subscribe to WXPress

Receive our newsletter and information on upcoming events.