As part of the collaboration between Merck KGaA and Pfizer to jointly develop and commercialize avelumab, the two global pharmaceutical giants announced that they have a collaboration agreement with Dako, an Agilent Technologies company headquartered in Santa Clara, CA, for the development of a potential companion diagnostic test (CDx).  Avelumab is an investigational fully human monoclonal antibody against programmed death-ligand 1 (anti-PD-L1).  Studies suggest that avelumab can potentially enable the activation of T cells and empower the adaptive immune system to fight cancer via antibody-dependent cell-mediated cytotoxicity mechanism.  The CDx aims to assess PD-L1 protein expression levels in tumor tissue and its microenvironment, including tumor-associated immune cells with the ultimate goal of achieving precision medicine.  This investigational CDx is part of the protocols in ongoing clinical trials involving avelumab according to the press release.


Original Article:$File/Alliance_Dako_US.pdf