The FDA has awarded pritumumab Orphan drug designation for the treatment of brain cancer. Brain cancer, especially glioblastoma is a rare and devastating cancer with poor prognosis. Pritumumab is a natural human antibody under development by the San Diego, CA-based biotech company, Nascent Biotech. It targets altered tumor-associated vimentin, a form of vimentin that is expressed only on the cell surface of a variety of tumors, including brain cancers and melanoma, but not expressed by normal tissue and cells (PMID: 19996527). Various Phase II clinical trials in Japan with pritumumab have shown significantly better results compared with standard therapy.