U.S. FDA has approved Gilead’s Descovy®, a fixed-dose combination for the treatment of HIV. Descovy (Emtricitabine, Tenofovir Alafenamide) is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 12 years of age and older. TAF is a novel targeted prodrug of tenofovir that has demonstrated high antiviral efficacy similar to and at a dose less than one-tenth that of Gilead’s Viread® (tenofovir disoproxil fumarate, TDF). TAF has also demonstrated improvement in surrogate laboratory markers of renal and bone safety as compared to TDF in clinical trials in combination with other antiretroviral agents. Descovy does not cure HIV infection or AIDS.