Steroid compounds hold an important position in modern drug discovery and development, from the introduction of cortisone in the 1940s for rheumatoid arthritis, to the advent of the oral contraceptive pill, which transformed reproductive health and the lives of millions of people. Today, steroids remain widely used in the treatment of cancer, immune disorders, and metabolic diseases...

The treatment paradigm for Alzheimer’s disease (AD) is undergoing a significant shift. Historically, drug development focused largely on improving cognitive and neuropsychiatric symptoms. Today, as our understanding of AD biology continues to deepen, the emphasis is increasingly moving toward slowing or modifying disease progression. Two trends are emerging in parallel. First, the target landscape is broadening beyond the classic amyloid-beta (Aβ) pathway to include Tau pathology, neuroinflammat

Though once associated with a tragic episode in pharmaceutical history, thalidomide was later repurposed through decades of mechanistic investigation, ultimately becoming an important starting point for molecular glue drug research. Its journey reflects the broader evolution of molecular glue degraders—from serendipitous discovery to increasingly rational design...

True answers withstand repeated scrutiny. In the synthesis of new drug molecules, what truly stands the test of time is not a single successful reaction, but a reliable process that can be repeated, scaled up, and proven over time. This forms the most fundamental and solid foundation of true professionalism...

The project delivered kilogram-scale GMP API within 8 months, reduced residual ruthenium in the final API by approximately 75-fold compared with the crude material, achieved a peptide solution above 100 mg/mL. Project onboarding to Phase 2 CTM release was completed in 11 months...

Oligonucleotide therapeutics are unlocking historically inaccessible disease targets. WuXi AppTec accelerates oligonucleotide drug discovery for central nervous system (CNS) diseases through an integrated discovery platform that bridging key capabilities required to move efficiently from target biology to candidate selection. This approach reduces discovery complexity and enables faster progression of promising programs...